Multiple sclerosis (MS) is a complex chronic disease with an unknown etiology. It is
considered an inflammatory demyelinating and neurodegenerative disorder of the central …

Introduction Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and
neurodegenerative condition affecting the central nervous system (CNS). Although …

In vitro investigations have revealed that consumption of selenium can considerably
decrease the expression of IFN-g in Th1 cells. A low plasma selenium content has been …

Demyelination in the central nervous system (CNS) is a hallmark of many
neurodegenerative diseases such as multiple sclerosis (MS) and others. Here, we studied …

Multiple sclerosis is characterized by demyelination and neuronal loss caused by
inflammatory cell activation and infiltration into the central nervous system. Macrophage …

Recent evidence suggests that the glucagon-like peptide-1 receptor (GLP-1R) agonists
have neuroprotective activities in the CNS in animal models of Parkinson's disease …

Abstract Background and Purpose ApTOLL is an aptamer selected to antagonize toll‐like
receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory responses in …

Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology
characterized by the loss of myelin (ie demyelination). The lack of myelin is followed by a …

Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune
signaling through Toll-like and interleukin-1 receptors and represents an attractive target for …

Introduction Gestational hypothyroxinemia (HTX) is a condition that occurs frequently at the
beginning of pregnancy, and it correlates with cognitive impairment, autism, and attentional …