[HTML][HTML] Pleural mesothelioma classification—update and challenges

S Dacic - Modern Pathology, 2022 - Elsevier
Mesothelial tumors are classified into benign or preinvasive tumors, and mesotheliomas.
The benign or preinvasive group includes adenomatoid tumors, well-differentiated papillary …

Pleural mesothelioma classification update

MB Beasley, F Galateau-Salle, S Dacic - Virchows Archiv, 2021 - Springer
The 2015 WHO classification of pleural mesotheliomas includes three major histologic
subtypes—epithelioid, sarcomatoid, and biphasic. Recent genomic data has supported the …

Treatment of malignant pleural mesothelioma: American Society of Clinical Oncology clinical practice guideline

HL Kindler, N Ismaila, SG Armato III… - Journal of Clinical …, 2018 - ascopubs.org
Purpose To provide evidence-based recommendations to practicing physicians and others
on the management of malignant pleural mesothelioma. Methods ASCO convened an …

[HTML][HTML] Update on biology and management of mesothelioma

R Asciak, V George, NM Rahman - European Respiratory …, 2021 - Eur Respiratory Soc
Malignant pleural mesothelioma is an aggressive, incurable cancer that is usually caused by
asbestos exposure several decades before symptoms arise. Despite widespread prohibition …

[HTML][HTML] Pembrolizumab as palliative immunotherapy in malignant pleural mesothelioma

Y Metaxas, G Rivalland, LA Mauti, D Klingbiel… - Journal of Thoracic …, 2018 - Elsevier
Introduction There is no approved second-line treatment for malignant pleural mesothelioma
(MPM). On the basis of promising early results, pembrolizumab was used off-label in …

NCCN guidelines insights: malignant pleural mesothelioma, version 3.2016

DS Ettinger, DE Wood, W Akerley… - Journal of the National …, 2016 - jnccn.org
These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for
Malignant Pleural Mesothelioma (MPM). These NCCN Guidelines Insights discuss systemic …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lung cancer and mesothelioma

R Govindan, C Aggarwal, SJ Antonia… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Immunotherapy has transformed lung cancer care in recent years. In addition to providing
durable responses and prolonged survival outcomes for a subset of patients with heavily …

Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma: The ATOMIC-Meso Randomized Clinical Trial

PW Szlosarek, BC Creelan, T Sarkodie, L Nolan… - JAMA …, 2024 - jamanetwork.com
Importance Arginine deprivation using ADI-PEG20 (pegargiminase) combined with
chemotherapy is untested in a randomized study among patients with cancer. ATOMIC …

[HTML][HTML] The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune …

C Kalla, G Ott, F Finotello, K Niewola-Staszkowska… - Translational …, 2024 - Elsevier
Targeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a
promising therapeutic strategy. We here investigated the effect of the novel and highly …

Use of preclinical models for malignant pleural mesothelioma

M Shamseddin, J Obacz, MJ Garnett, RC Rintoul… - Thorax, 2021 - thorax.bmj.com
Malignant pleural mesothelioma (MPM) is an aggressive cancer most commonly caused by
prior exposure to asbestos. Median survival is 12–18 months, since surgery is ineffective …