Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living
organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell …

The polyamines putrescine, spermidine, and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …

Polyamines are ubiquitous positively charged amines found in all organisms. These
molecules play a crucial role in many biological functions including cell growth, gene …

Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum
of neurodegenerative disorders, including Parkinson's disease (PD). We recently revealed …

High incidences of morbidity and mortality associated with age-related diseases among the
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …

Background: Spermidine, a naturally occurring polyamine, has recently emerged as
exhibiting anti-aging properties. Its supplementation increases lifespan and resistance to …

Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are
essential for eukaryotic cell growth. These polycations interact with negatively charged …

Polyamines are organic polycations that bind to a variety of cellular molecules, including
nucleic acids. Within cells, polyamines contribute to both the efficiency and fidelity of protein …

Polyamines (PAs) have been considered as important molecules for survival. However,
evidence reinforces that PAs are also implicated, directly or indirectly, in pathways …

In life, genetic and epigenetic networks precisely coordinate the expression of genes—but in
death, it is not known if gene expression diminishes gradually or abruptly stops or if specific …