The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
Identification of a Putative SARS-CoV-2 Main Protease Inhibitor through In Silico Screening of Self-Designed Molecular Library
N Liu, Z Yang, Y Liu, X Dang, Q Zhang, J Wang… - International journal of …, 2023 - mdpi.com
There have been outbreaks of SARS-CoV-2 around the world for over three years, and its
variants continue to evolve. This has become a major global health threat. The main …
variants continue to evolve. This has become a major global health threat. The main …
Recent Advances in Signaling Pathways and Kinase Inhibitors for Leukemia Chemotherapy
Y Liu, Z Yang, Q Zhang, P Hai, Y Zheng… - Current Medicinal …, 2024 - ingentaconnect.com
Leukemia is a malignant clonal disease of hematopoietic stem cells, which accounts for
about 3% of the total incidence of tumors and is particularly prevalent among children and …
about 3% of the total incidence of tumors and is particularly prevalent among children and …
Targeted delivery of panitumumab-scaffold bosutinib-encapsulated polycaprolactone nanoparticles for EGFR-overexpressed colorectal cancer
S Bhattacharya, VK Parihar, N Singh, K Hatware… - …, 2023 - Taylor & Francis
Aims: Panitumumab (anti-Erb)-conjugated polycaprolactone (PCL) nanoparticles loaded
with bosutinib (BTNB) were used to develop a targeted drug-delivery system for colon …
with bosutinib (BTNB) were used to develop a targeted drug-delivery system for colon …
Current Scenario of Pyridine/Quinoline-Sulfonamide Hybrids with Anticancer Potential (A Review)
GL Dong, YP Feng, JJ Wang, X Sun - Russian Journal of General …, 2024 - Springer
Cancer, which proliferates and spreads uncontrollably due to the accumulation of genetic
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
A Potential Molecular Inhibitor of the SARS-COV-2 Main Protease Obtained by Virtual Screening
N Liu, Z Yang, Y Liu, X Dang, Q Zhang, J Wang, X Liu… - 2023 - researchsquare.com
SARS-CoV-2 has been out breaking around the world for more than three years and
continues to evolve variants, which has become a major global health threat. Main protease …
continues to evolve variants, which has become a major global health threat. Main protease …