Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78
Oxygen (O2) sensing by the carotid body is critical for maintaining cardiorespiratory
homeostasis during hypoxia. Hydrogen sulfide (H2S) signaling is implicated in carotid body …
homeostasis during hypoxia. Hydrogen sulfide (H2S) signaling is implicated in carotid body …
The superior cervical ganglia modulate ventilatory responses to hypoxia independently of preganglionic drive from the cervical sympathetic chain
PM Getsy, GA Coffee, YH Hsieh… - Journal of Applied …, 2021 - journals.physiology.org
Superior cervical ganglia (SCG) postganglionic neurons receive preganglionic drive via the
cervical sympathetic chains (CSC). The SCG projects to structures like the carotid bodies …
cervical sympathetic chains (CSC). The SCG projects to structures like the carotid bodies …
[HTML][HTML] Revisiting cAMP signaling in the carotid body
Chronic carotid body (CB) activation is now recognized as being essential in the
development of hypertension and promoting insulin resistance; thus, it is imperative to …
development of hypertension and promoting insulin resistance; thus, it is imperative to …
Adrenaline activation of the carotid body: Key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease
Ventilatory and neuroendocrine counter-regulatory responses during hypoglycaemia are
essential in order to maintain glycolysis and prevent rises in P a CO 2 leading to systemic …
essential in order to maintain glycolysis and prevent rises in P a CO 2 leading to systemic …
[HTML][HTML] Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation
L Zhang, H Jin, Y Song, SY Chen, Y Wang… - Journal of Advanced …, 2021 - Elsevier
Introduction Mast cell (MC) degranulation is an important step in the pathogenesis of
inflammatory reactions and allergies; however, the mechanism of stabilizing MC membranes …
inflammatory reactions and allergies; however, the mechanism of stabilizing MC membranes …
[HTML][HTML] Loss of cervical sympathetic chain input to the superior cervical ganglia affects the ventilatory responses to hypoxic challenge in freely-moving C57BL6 mice
PM Getsy, GA Coffee, YH Hsieh, SJ Lewis - Frontiers in Physiology, 2021 - frontiersin.org
The cervical sympathetic chain (CSC) innervates post-ganglionic sympathetic neurons
within the ipsilateral superior cervical ganglion (SCG) of all mammalian species studied to …
within the ipsilateral superior cervical ganglion (SCG) of all mammalian species studied to …
Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to …
CD Lee, WS Choi, YG Choi, HS Kang… - Journal of …, 2020 - journals.sagepub.com
Objective Asthma is a chronic inflammatory disease that can lead to severe problems with
the respiratory system. This study aimed to evaluate the suppression of allergic airway …
the respiratory system. This study aimed to evaluate the suppression of allergic airway …
[HTML][HTML] β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia
AA Alzahrani, LL Cao, HS Aldossary… - … -European Journal of …, 2021 - Springer
Carotid body (CB) hyperactivity promotes hypertension in response to chronic intermittent
hypoxia (CIH). The plasma concentration of adrenaline is reported to be elevated in CIH and …
hypoxia (CIH). The plasma concentration of adrenaline is reported to be elevated in CIH and …
Enhanced adenosine A2b receptor signaling facilitates stimulus-induced catecholamine secretion in chronically hypoxic carotid body type I cells
S Livermore, CA Nurse - American Journal of Physiology …, 2013 - journals.physiology.org
Chronic hypoxia (CHox) augments chemoafferent activity in sensory fibers innervating
carotid body (CB) chemoreceptor type I cells; however, the underlying mechanisms are …
carotid body (CB) chemoreceptor type I cells; however, the underlying mechanisms are …
Lessons from single-cell transcriptome analysis of oxygen-sensing cells
T Zhou, H Matsunami - Cell and tissue research, 2018 - Springer
The advent of single-cell RNA-sequencing (RNA-Seq) technology has enabled
transcriptome profiling of individual cells. Comprehensive gene expression analysis at the …
transcriptome profiling of individual cells. Comprehensive gene expression analysis at the …