Formate, the only non-tetrahydrofolate (THF)-linked intermediate in one-carbon metabolism,
is produced in mammals from a variety of metabolic sources. It occurs in serum of adults at a …

There is a strong biological premise for including vitamin B12 with folic acid in strategies to
prevent neural tube defects (NTDs), due to the closely interlinked metabolism of these two …

Metabolic vulnerability is associated with age-related diseases and concomitant co-
morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health …

Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the
third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 to 200 per …

Spinal bifida aperta (SBA) is a congenital malformation with a high incidence. Bone marrow
mesenchymal stem cell (BMSC) transplantation has the potential to repair the structure of …

BACKGROUND In previous studies, we found that the deficiency of sensory and motor
neurons was a primary defect associated with the spinal malformation. Upon prenatal …

Robustness is a feature of regulatory pathways to ensure signal consistency in light of
environmental changes or genetic polymorphisms. The retinoic acid (RA) pathway, is a …

Abstract Introduction: Neural tube defects (NTDs) are among the most debilitating and
common developmental defects in humans. The induction of NTDs has been attributed to …

A dihydrofolate reductase 2 (DHFR2) variant is associated with risk of neural tube defects in an
Irish cohort but not in a United Kingdom cohort A dihydrofolate reductase 2 (DHFR2) variant is …

ABSTRACT Adenosine deaminase-1 (ADA1) regulates the concentration of adenosine as
the main modulator of oocyte maturation. There is compelling evidence for the association of …