Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

Breast cancer (BC) is a complex and heterogeneous disease, and oxidative stress is a
hallmark of BC. Oxidative stress is characterized by an imbalance between the production of …

BRD4 is a member of the BET protein family involved in chromatin remodeling and
transcriptional regulation. Several BET inhibitors (BETi) have entered clinical trials …

Abstract SARS-CoV-2 Envelope protein (E) is one of the crucial components in virus
assembly and pathogenesis. The current study investigated its role in the SARS-CoV-2 …

Proteolysis targeting chimeras (PROTACs) is a promising strategy for cancer therapy.
However, the always-on bioactivity of PROTACs may lead to non-target toxicity, which …

Polycystic ovary syndrome (PCOS) is an endocrine disorder and the main cause of
anovulatory infertility, in which persistent activation of androgen receptor (AR) due to …

In this study, we present the synthesis and incorporation of a metabolic isoleucine precursor
compound for selective methylene labeling. The utility of this novel α-ketoacid isotopologue …

Abstract Treatment of cancer is now in a phase of new possibilities, and with the targeted
therapy, the advancement of the therapy is considered as the next generation of cancer …

Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cancer,
accounting for approximately 80% of all renal cell cancers. Due to its exceptional inter-and …

Prostate cancer (PCa) is a complex disease and the cause of one of the highest cancer-
related mortalities in men worldwide. Annually, more than 1.2 million new cases are …