How chemokines organize the tumour microenvironment
TR Mempel, JK Lill, LM Altenburger - Nature Reviews Cancer, 2024 - nature.com
For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk
RV Hewavisenti, J Arena, CL Ahlenstiel… - Frontiers in …, 2023 - frontiersin.org
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …
CXCL12-CXCR4/CXCR7 axis in colorectal cancer: therapeutic target in preclinical and clinical studies
T Khare, M Bissonnette, S Khare - International journal of molecular …, 2021 - mdpi.com
Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …
CXCR4/CXCL12 activities in the tumor microenvironment and implications for tumor immunotherapy
R Mezzapelle, M Leo, F Caprioglio, LS Colley… - Cancers, 2022 - mdpi.com
Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …
CXCR4 and CXCR7 signaling pathways: a focus on the cross-talk between cancer cells and tumor microenvironment
S Santagata, C Ieranò, AM Trotta, A Capiluongo… - Frontiers in …, 2021 - frontiersin.org
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …
(GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They …
[HTML][HTML] Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis
Global microplastic (MP) contamination and the effects on the environment are well
described. However, the potential for MP consumption to affect human health remains …
described. However, the potential for MP consumption to affect human health remains …
Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis
S Sun, D Wang, D Dong, L Xu, M Xie, Y Wang, T Ni… - Critical Care, 2023 - Springer
Background The gut microbiome plays a pivotal role in the progression of sepsis. However,
the specific mechanism of gut microbiota and its metabolites involved in the process of …
the specific mechanism of gut microbiota and its metabolites involved in the process of …
[HTML][HTML] Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
EH Ervin, R French, CH Chang, S Pauklin - Seminars in cancer biology, 2022 - Elsevier
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
Patient selection for CAR T or BiTE therapy in multiple myeloma: Which treatment for each patient?
D Kegyes, C Constantinescu, L Vrancken… - Journal of Hematology & …, 2022 - Springer
Multiple myeloma (MM) is a plasma cell malignancy that affects an increasing number of
patients worldwide. Despite all the efforts to understand its pathogenesis and develop new …
patients worldwide. Despite all the efforts to understand its pathogenesis and develop new …
Role of chemokine systems in cancer and inflammatory diseases
H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …
organ development, normal physiology, and immune responses upon binding to their …