Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

CJ Chao, E Zhang, Z Zhao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …

In situ cellular hitchhiking of nanoparticles for drug delivery

E Udofa, Z Zhao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Since the inception of the concept of “magic bullet”, nanoparticles have evolved to be one of
the most effective carriers in drug delivery. Nanoparticles improve the therapeutic efficacy of …

Nanoparticles hitchhike on monocytes for glioblastoma treatment after low-dose radiotherapy

J Kuang, ZY Rao, DW Zheng, D Kuang, QX Huang… - ACS …, 2023 - ACS Publications
Glioblastomas (GBMs) are aggressive primary brain tumors with fatal outcome. Traditional
chemo-radiotherapy has poor therapeutic effect and significant side effects, due to the drug …

Current understanding of passive and active targeting nanomedicines to enhance tumor accumulation

Z Chen, RK Kankala, L Long, S Xie, AZ Chen… - Coordination Chemistry …, 2023 - Elsevier
In recent years, tremendous advancements in nanomedicine have resulted in the rapid
development of various nanoformulations, especially the treatment of solid tumors. Despite …

Systemic tumor suppression via macrophage‐driven automated homing of metal‐phenolic‐gated nanosponges for metastatic melanoma

X Liao, G Gong, M Dai, Z Xiang, J Pan, X He… - Advanced …, 2023 - Wiley Online Library
Cell‐based therapies comprising the administration of living cells to patients for direct
therapeutic activities have experienced remarkable success in the clinic, of which …

Knowledge gaps in generating cell-based drug delivery systems and a possible meeting with artificial intelligence

N Mozafari, N Mozafari, A Dehshahri… - Molecular …, 2023 - ACS Publications
Cell-based drug delivery systems are new strategies in targeted delivery in which cells or
cell-membrane-derived systems are used as carriers and release their cargo in a controlled …

Exosomes-based nanomedicine for neurodegenerative diseases: current insights and future challenges

A Cano, Á Muñoz-Morales, E Sánchez-López… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases constitute a group of pathologies whose etiology remains
unknown in many cases, and there are no treatments that stop the progression of such …

“Hook&Loop” multivalent interactions based on disk-shaped nanoparticles strengthen active targeting

N Dong, Z Liu, H He, Y Lu, J Qi, W Wu - Journal of Controlled Release, 2023 - Elsevier
How to enhance active targeting efficiency remains a challenge. Multivalent interactions play
a crucial role in improving the binding ability between ligands and receptors. It is …

Biomimetic nano-drug delivery system: an emerging platform for promoting tumor treatment

X Han, C Gong, Q Yang, K Zheng, Z Wang… - International Journal of …, 2024 - Taylor & Francis
With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects
as drug delivery vehicles. However, they exhibit certain limitations, including low …

[HTML][HTML] Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

X Liu, Y Cheng, Y Liu, X Hu, T Wen - Frontiers in Immunology, 2024 - frontiersin.org
Despite the clear benefits demonstrated by immunotherapy, there is still an inevitable off-
target effect resulting in serious adverse immune reactions. In recent years, the research and …