The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …

Classically, the basal ganglia have been considered to have a role in producing habitual
and goal-directed behaviours. In this article, we review recent evidence that expands this …

Background As greater numbers of us are living longer, it is increasingly important to
understand how we can age healthily. Although old age is often stereotyped as a time of …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Altered inhibitory control (response inhibition, reward-based inhibition, cognitive inhibition,
reversal learning) has been implicated in eating disorders (EDs) and obesity. It is unclear …

Communication between the prefrontal cortex and subcortical nuclei underpins the control
and inhibition of behavior. However, the interactions in such pathways remain controversial …

Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …

Apathy and impulsivity are common and disabling consequences of frontotemporal lobar
degeneration. They cause substantial carer distress, but their aetiology remains elusive …

Behavioural disinhibition is a common feature of the syndromes associated with
frontotemporal lobar degeneration (FTLD). It is associated with high morbidity and lacks …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of …