Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping

CA Nicolau, A Prorock, Y Bao, AGC Neves-Ferreira… - Toxins, 2018 - mdpi.com
Snake venoms are sources of molecules with proven and potential therapeutic applications.
However, most activities assayed in venoms (or their components) are of hemorrhagic …

Altered functional interactions of inhibition regions in cognitively normal Parkinson's disease

DL Harrington, Q Shen, RJ Theilmann… - Frontiers in aging …, 2018 - frontiersin.org
Deficient inhibitory control in Parkinson's disease (PD) is often observed in situations
requiring inhibition of impulsive or prepotent behaviors. Although activation of the right …

The motor inhibitory network in patients with asymmetrical Parkinson's disease: An fMRI study

FR Loayza, I Obeso, RG Redondo, F Villagra… - Brain Imaging and …, 2022 - Springer
Recent imaging studies with the stop-signal task in healthy individuals indicate that the
subthalamic nucleus, the pre-supplementary motor area and the inferior frontal gyrus are …

Neuroimaging approaches to cognition in Parkinson's disease

L Montaser-Kouhsari, CB Young, KL Poston - Progress in Brain Research, 2022 - Elsevier
While direct visualization of Lewy body accumulation within the brain is not yet possible in
living Parkinson's disease patients, brain imaging studies offer insights into how the buildup …

Long-Term Wu Qin Xi Exercise on Response Inhibition and Cortical Connectivity in Parkinson's Disease: Design and Implementation of a Randomized Controlled …

Z Wang, LL Zhang, Y Wu, J Zhang, K Liu - Frontiers in Neurology, 2021 - frontiersin.org
Background: Motor symptom disorders in patients with Parkinson disease (PD) are closely
related to reduced inhibitory ability. Although exercise has been shown to improve this …

Cognitive function in Parkinson's disease patients with and without anxiety

KA Ehgoetz Martens, JYY Szeto… - Neurology research …, 2016 - Wiley Online Library
Research on the implications of anxiety in Parkinson's disease (PD) has been neglected
despite its prevalence in nearly 50% of patients and its negative impact on quality of life …

Psychopharmacological Options for Treating Impulsivity.

JE Grant, SR Chamberlain - Psychiatric Times, 2015 - search.ebscohost.com
The article reviews psychopharmacological options for treating impulsivity and discusses the
extent of their efficacy in reducing impulsivity. The psychopharmacological options reviewed …

The role of central serotonin in impulsivity, compulsivity, and decision-making: comparative studies in experimental animals and humans

BU Phillips, TW Robbins - Handbook of Behavioral Neuroscience, 2020 - Elsevier
We review the role of 5-HT systems in constructs of impulsivity and compulsivity, as well as
decision-making cognition, in the context of modern reinforcement learning theory. Data …

Impulse control disorders are associated with multiple psychiatric symptoms in Parkinson's disease

E Jaakkola, V Kaasinen, C Siri… - Journal of …, 2014 - content.iospress.com
Background: Impulse control disorders can have serious adverse consequences to the life of
a patient with Parkinson's disease. Although impulse control disorders are common, a …

Cognitive deficits in Parkinson's disease: current perspectives

J Cosgrove, JE Alty - Journal of Parkinsonism and Restless Legs …, 2018 - Taylor & Francis
Cognitive dysfunction is a common and significant non-motor symptom of Parkinson's
disease (PD). PD mild cognitive impairment (PD-MCI) is evident in approximately one …