Microfluidic formulation of topological hydrogels for microtissue engineering

KO Rojek, M Cwiklinska, J Kuczak… - Chemical …, 2022 - ACS Publications
Microfluidics has recently emerged as a powerful tool in generation of submillimeter-sized
cell aggregates capable of performing tissue-specific functions, so-called microtissues, for …

Synthesis of lipid membranes for artificial cells

KA Podolsky, NK Devaraj - Nature Reviews Chemistry, 2021 - nature.com
A major goal of synthetic biology is to understand the transition between non-living matter
and life. The bottom-up development of an artificial cell would provide a minimal system with …

Superstructural ordering in self-sorting coacervate-based protocell networks

W Mu, L Jia, M Zhou, J Wu, Y Lin, S Mann, Y Qiao - Nature Chemistry, 2024 - nature.com
Bottom-up assembly of higher-order cytomimetic systems capable of coordinated physical
behaviours, collective chemical signalling and spatially integrated processing is a key …

A microscale soft ionic power source modulates neuronal network activity

Y Zhang, J Riexinger, X Yang, E Mikhailova, Y Jin… - Nature, 2023 - nature.com
Bio-integrated devices need power sources to operate,. Despite widely used technologies
that can provide power to large-scale targets, such as wired energy supplies from batteries …

Signal processing and generation of bioactive nitric oxide in a model prototissue

S Liu, Y Zhang, X He, M Li, J Huang, X Yang… - Nature …, 2022 - nature.com
The design and construction of synthetic prototissues from integrated assemblies of artificial
protocells is an important challenge for synthetic biology and bioengineering. Here we …

Droplet printing reveals the importance of micron-scale structure for bacterial ecology

R Krishna Kumar, TA Meiller-Legrand… - Nature …, 2021 - nature.com
Bacteria often live in diverse communities where the spatial arrangement of strains and
species is considered critical for their ecology. However, a test of this hypothesis requires …

Facile and programmable capillary-induced assembly of prototissues via hanging drop arrays

C Qi, X Ma, J Zhong, J Fang, Y Huang, X Deng… - ACS …, 2023 - ACS Publications
An important goal for bottom-up synthetic biology is to construct tissue-like structures from
artificial cells. The key is the ability to control the assembly of the individual artificial cells …

Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation

J Li, WD Jamieson, P Dimitriou, W Xu, P Rohde… - Nature …, 2022 - nature.com
Intracellular compartments are functional units that support the metabolism within living
cells, through spatiotemporal regulation of chemical reactions and biological processes …

Reversible deformation of artificial cell colonies triggered by actin polymerization for muscle behavior mimicry

C Li, X Zhang, B Yang, F Wei, Y Ren, W Mu… - Advanced …, 2022 - Wiley Online Library
The use of artificial cells to mimic living tissues is beneficial for understanding the
mechanism of interaction among cells. Artificial cells hold immense potential in the field of …

Smart droplets stabilized by designer surfactants: from biomimicry to active motion to materials healing

Z Yang, D Snyder, A Sathyan, A Balazs… - Advanced Functional …, 2023 - Wiley Online Library
The science and technologies of emulsion droplets have been a long‐term focus of
extensive research endeavors for their practical utility across a breadth of industries …