Hydrocephalus is classically considered as a failure of cerebrospinal fluid (CSF)
homeostasis that results in the active expansion of the cerebral ventricles. Infants with …

Thrombin is increased in the brain after hemorrhagic and ischemic stroke primarily due to
the prothrombin entry from blood either with a hemorrhage or following blood-brain barrier …

Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to
arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical …

Introduction Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic
events such as intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH) …

Objective To compare neurodevelopmental outcomes of preterm infants with and without
intervention for posthemorrhagic ventricular dilatation (PHVD) managed with an “early …

Mohamed El-Dib, MD1, David D. Limbrick, Jr, MD, PhD2, Terrie Inder, MBCHB, MD1,
Andrew Whitelaw, MD3, Abhaya V. Kulkarni, MD, PhD4, Benjamin Warf, MD5, Joseph J …

Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

Current therapies for reducing raised intracranial pressure (ICP) under conditions such as
idiopathic intracranial hypertension or hydrocephalus have limited efficacy and tolerability …

Pharmacological interventions have been tested experimentally and clinically to prevent
hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of …

Purpose Intraventricular hemorrhage is the most important adverse neurologic event for
preterm and very low weight birth infants in the neonatal period. This pathology can lead to …