Abstract Type 2 diabetes (T2D) is a global health problem characterised by chronic
hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised …

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones
insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and …

BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1
diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only …

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells …

Aim/hypothesis Hyperglycaemia is associated with alpha cell dysfunction, leading to
dysregulated glucagon secretion in type 1 and type 2 diabetes; however, the mechanisms …

There is a growing understanding that the early phases of type 1 diabetes (T1D) are
characterised by a deleterious dialogue between the pancreatic beta cells and the immune …

Six flavonoids, namely, three undescribed biflavonoids, one undescribed 8-aryl flavonoid,
and two known compounds, were isolated from Selaginella tamariscina (P. Beauv.) Spring …

The importance of glucokinase (GK) in the regulation of insulin secretion has been
highlighted by the phenotypes of individuals with activating and inactivating mutations in the …