Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Carbapenem resistance is a major and an on-going public health problem globally. It occurs
mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas …

Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

Urinary tract infections (UTIs) are recognized as one of the most common infectious
diseases in the world that can be divided to different types. Uropathogenic Escherichia coli …

Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐
priority pathogens owing to their high association with mortalities and morbidities …

La introducción de los antibióticos en la práctica clínica supuso una de las intervenciones
más importantes para el control de las enfermedades infecciosas. Los antibióticos han …

The emergence and spread of carbapenem-resistant Gram-negative pathogens is a global
public health problem. The acquisition of metallo-β-lactamases (MBLs) such as NDM-1 is a …

ABSTRACT Cefiderocol (S-649266) is a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety at the third-position side chain. The in vitro activity of …

β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to
the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both …