The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …

Abstract Background Patients with Alzheimer's disease (AD) are often co-morbid with
unprovoked seizures, making clinical diagnosis and management difficult. Although it has …

Arising out of a PhD project more than 50 years ago to synthesise analogues of the
neurotransmitter GABA, a series of new chemical entities were found to have selective …

Background Use proton magnetic resonance spectroscopy (1H-MRS) non invasive
technique to assess the modifications of glutamate-glutamine (Glx) and gammaaminobutyric …

Neuropsychiatric and neurological disorders pose a significant global health burden,
highlighting the need for innovative therapeutic approaches. Fingolimod (FTY720), a …

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. In the mature brain, inhibitory GABAergic signaling is critical in maintaining …

Background: Alzheimer's disease (AD) and epilepsy represent two complex neurological
disorders with distinct clinical manifestations, yet recent research has highlighted their …

The goal of the treatment for Alzheimer's dementia (AD) is the cure of dementia. A literature
review revealed 18 major elements causing AD and 29 separate medications that address …

Several proteases are involved in the proteolytic processing of the amyloid precursor protein
(APP) generating the amyloidogenic Aβ peptide, which can act as the triggering pathological …