[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Cellular nanosponges for biological neutralization

S Wang, D Wang, Y Duan, Z Zhou, W Gao… - Advanced …, 2022 - Wiley Online Library
Biological neutralization represents a general strategy that deploys therapeutic agents to
bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent …

Deep-STP: a deep learning-based approach to predict snake toxin proteins by using word embeddings

H Zulfiqar, Z Guo, RM Ahmad, Z Ahmed, P Cai… - Frontiers in …, 2024 - frontiersin.org
Snake venom contains many toxic proteins that can destroy the circulatory system or
nervous system of prey. Studies have found that these snake venom proteins have the …

[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

[HTML][HTML] Potassium channels as a target for cancer therapy: Current perspectives

L Zúñiga, A Cayo, W González, C Vilos… - OncoTargets and …, 2022 - ncbi.nlm.nih.gov
Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …

Navigating the chemical space and chemical multiverse of a unified Latin American natural product database: LANaPDB

A Gómez-García, DAA Jiménez, WJ Zamora… - Pharmaceuticals, 2023 - mdpi.com
The number of databases of natural products (NPs) has increased substantially. Latin
America is extraordinarily rich in biodiversity, enabling the identification of novel NPs, which …

Progress and impact of Latin American natural product databases

A Gómez-García, JL Medina-Franco - Biomolecules, 2022 - mdpi.com
Natural products (NPs) are a rich source of structurally novel molecules, and the chemical
space they encompass is far from being fully explored. Over history, NPs have represented a …

A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients

Z Fu, H Sun, Y Wu, C Li, Y Wang, Y Liu, Y Li, J Nie… - NPG Asia …, 2022 - nature.com
The combined use of peptides, nanomaterials, and hydrogels is a promising strategy for
chronic skin wound healing, which remains a huge clinical challenge. Here, we optimized …

Neurotoxins acting at synaptic sites: A brief review on mechanisms and clinical applications

K Zhou, W Luo, T Liu, Y Ni, Z Qin - Toxins, 2022 - mdpi.com
Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Peptides from marine-derived Fungi: chemistry and biological activities

S Hafez Ghoran, F Taktaz, E Sousa, C Fernandes… - Marine Drugs, 2023 - mdpi.com
Marine natural products are well-recognized as potential resources to fill the pipeline of drug
leads to enter the pharmaceutical industry. In this circumstance, marine-derived fungi are …