Chagas disease is a chronic and potentially lethal disorder caused by the parasite
Trypanosoma cruzi, and an effective treatment has not been developed for chronic Chagas …

Although debate continues, there is agreement that dogs (Canis lupus familiaris) were first
domesticated in Eurasia, spreading from there to other parts of the world. However, while …

Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is a
leading cause of heart disease (“chagasic cardiomyopathy”) in Latin America …

Chagas disease, caused by infection with Trypanosoma cruzi, is an important disease of
humans and dogs in the Americas. Here, we review aspects of canine Chagas disease with …

Biomarkers (coming from host or parasite) to monitor Chagas disease (CD) progression as
well as the therapeutic response in chronic CD are critically needed, since …

Parasitic diseases cause∼ 500,000 deaths annually and remain a major challenge for
therapeutic development. Using a rational design based approach, we developed peptide …

Chagas disease (American trypanosomiasis caused by T rypanosoma cruzi) is one of the
most important neglected tropical diseases in the W estern H emisphere. The toxicities and …

Simple Summary Chagas disease (ChD) has become one of the biggest public-health
problems in Latin America due to its incapacitating effects and mortality rates. Therefore, it is …

Dogs play a major role in the domestic cycle of Trypanosoma cruzi, acting as reservoirs. In a
previous work we have developed a model of vaccination of dogs in captivity with …

B-cell superantigens (BC-SAgs) are immunoevasins that have evolved in response to innate
catalytic IgM antibodies; germ-line encoded immunoglobulins present in the preimmune …