Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …

Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, and there
is no effective clinical treatment, to date. Due to the complex pathological process involved …

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

Bio-factor stimulation is essential for axonal regeneration in the central nervous system.
Thus, persistent and efficient factor delivery in the local microenvironment is an ideal …