[HTML][HTML] Curcumin: An epigenetic regulator and its application in cancer

T Ming, Q Tao, S Tang, H Zhao, H Yang, M Liu… - Biomedicine & …, 2022 - Elsevier
Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy

J Ye, J Wu, B Liu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …

Macrophages‐Based Biohybrid Microrobots for Breast Cancer Photothermal Immunotherapy by Inducing Pyroptosis

G Xing, X Yu, Y Zhang, S Sheng, L Jin, D Zhu, L Mei… - Small, 2024 - Wiley Online Library
Pyroptosis‐based immunotherapy can escape drug resistance as well as inhibit metastasis.
It is urgently required to develop a delivery platform to induce targeted tumor‐specific …

Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy

F Ding, J Liu, K Ai, C Xu, X Mao, Z Liu… - Advanced …, 2024 - Wiley Online Library
Promoting innate immunity through pyroptosis induction or the cyclic GMP‐AMP synthase‐
stimulator of interferon gene (cGAS‐STING) pathway activation has emerged as a potent …

DNA methyltransferases: from evolution to clinical applications

VM Del Castillo Falconi, K Torres-Arciga… - International journal of …, 2022 - mdpi.com
DNA methylation is an epigenetic mark that living beings have used in different
environments. The MTases family catalyzes DNA methylation. This process is conserved …

Cancer stem cells and their possible implications in cervical cancer: a short review

R Di Fiore, S Suleiman, R Drago-Ferrante… - International journal of …, 2022 - mdpi.com
Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting
females worldwide. Most CC cases are linked to infection with high-risk human …

Harnessing epigenetics for breast cancer therapy: The role of DNA methylation, histone modifications, and microRNA

J Szczepanek, M Skorupa, J Jarkiewicz-Tretyn… - International Journal of …, 2023 - mdpi.com
Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

Melatonin: a potential regulator of DNA methylation

K Linowiecka, AT Slominski, RJ Reiter, M Böhm… - Antioxidants, 2023 - mdpi.com
The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular
processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to …

Novel therapeutic strategies for chronic hepatitis B

S Phillips, R Jagatia, S Chokshi - Virulence, 2022 - Taylor & Francis
The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with
many compounds in various stages of development. This review aims to provide a …

Crosstalk between miRNAs and DNA Methylation in Cancer

M Saviana, P Le, L Micalo, D Del Valle-Morales… - Genes, 2023 - mdpi.com
miRNAs are some of the most well-characterized regulators of gene expression. Integral to
several physiological processes, their aberrant expression often drives the pathogenesis of …