Inflammaging and osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
worldwide. While in the past it was considered a mere consequence of cartilage degradation …
[HTML][HTML] Aging hallmarks and the role of oxidative stress
E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …
function of the organism and an increased risk of age-related chronic diseases such as …
[HTML][HTML] The aging lung: Physiology, disease, and immunity
JL Schneider, JH Rowe, C Garcia-de-Alba, CF Kim… - Cell, 2021 - cell.com
The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021 - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
[HTML][HTML] The role of inflammation in diabetic retinopathy
JV Forrester, L Kuffova, M Delibegovic - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …
syndrome and particularly implicates innate immunity in the development of complications …
[HTML][HTML] A complex systems approach to aging biology
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …
aging biology research is now moving toward integration of these parts, attempting to …
The multiple roles of life stress in metabolic disorders
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …
excessive stress can damage body functions. We review current evidence from basic …
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …