Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Towards a youth mental health paradigm: a perspective and roadmap

PJ Uhlhaas, CG Davey, UM Mehta, J Shah… - Molecular …, 2023 - nature.com
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

The lived experience of psychosis: a bottom‐up review co‐written by experts by experience and academics

P Fusar‐Poli, A Estradé, G Stanghellini… - World …, 2022 - Wiley Online Library
Psychosis is the most ineffable experience of mental disorder. We provide here the first co‐
written bottom‐up review of the lived experience of psychosis, whereby experts by …

Meta-analytic prevalence of comorbid mental disorders in individuals at clinical high risk of psychosis: the case for transdiagnostic assessment

M Solmi, L Soardo, S Kaur, M Azis, A Cabras… - Molecular …, 2023 - nature.com
Comorbid mental disorders in subjects at clinical high risk for psychosis (CHR-P) may
impact preventive care. We conducted a PRISMA/MOOSE-compliant systematic meta …

[HTML][HTML] Cognitive dysfunction in schizophrenia: an expert group paper on the current state of the art

PD Harvey, M Bosia, R Cavallaro, OD Howes… - Schizophrenia Research …, 2022 - Elsevier
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and
functional recovery. This expert group paper brings together experts in schizophrenia …

The course of general cognitive ability in individuals with psychotic disorders

K Jonas, W Lian, J Callahan, CJ Ruggero… - JAMA …, 2022 - jamanetwork.com
Importance Schizophrenia is associated with major cognitive deficits and has been
conceptualized as both a neurodevelopmental and a neurodegenerative disorder. However …

Arketamine for cognitive impairment in psychiatric disorders

K Hashimoto - European Archives of Psychiatry and Clinical …, 2023 - Springer
Cognitive impairment has been observed in patients with various psychiatric disorders,
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …

Prevalence of individuals at clinical high-risk of psychosis in the general population and clinical samples: systematic review and meta-analysis

G Salazar de Pablo, SW Woods, G Drymonitou… - Brain sciences, 2021 - mdpi.com
(1) The consistency and magnitude of the prevalence of Clinical High-Risk for Psychosis
(CHR-P) individuals are undetermined, limiting efficient detection of cases. We aimed to …

Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline

RM Murray, E Bora, G Modinos, A Vernon - Schizophrenia Research, 2022 - Elsevier
The onset of schizophrenia is determined by biological and social risk factors operating
predominantly during development. These result in subtle deviations in brain structure and …

Psychotic disorders as a framework for precision psychiatry

F Coutts, N Koutsouleris, P McGuire - Nature Reviews Neurology, 2023 - nature.com
People with psychotic disorders can show marked interindividual variations in the onset of
illness, responses to treatment and relapse, but they receive broadly similar clinical care …