Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

The transcriptional and metabolic programmes that control CD8+ T cells are regulated by a
diverse network of serine/threonine kinases. The view has been that the kinases AKT and …

MicroRNA (miRNA) are a class of post‐transcriptional regulators of gene expression
targeting mRNA for translational repression and/or degradation. We analyzed the …

During a T cell response, the effector CTL pool contains two cellular subsets: short-lived
effector cells (SLECs), a majority of which are destined for apoptosis, and the memory …

To detect targeted antileukemia agents we have designed a novel, high-content in vivo
screen using genetically engineered, T-cell reporting zebrafish. We exploited the …

The tumor suppressor phosphatase and tensin homolog (PTEN) is a lipid and protein
phosphatase that is able to antagonize the PI3K/AKT pathway and inhibit tumor growth …

Background Systemic lupus erythematosus (SLE) is a chronic and incurable autoimmune
disease involving the dysfunction of lymphocytes. Circular RNAs (circRNAs) are noncoding …

Interleukin (IL)-7 is required for T-cell development as well as for the survival and
homeostasis of mature T-cells. In the thymus, the double negative (DN) CD4− CD8 …