Recurrent pregnancy loss

E Dimitriadis, E Menkhorst, S Saito… - Nature reviews disease …, 2020 - nature.com
Recurrent pregnancy loss is a distressing pregnancy disorder experienced by~ 2.5% of
women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more …

[HTML][HTML] Endometrial immune dysfunction in recurrent pregnancy loss

C Ticconi, A Pietropolli, N Di Simone… - International journal of …, 2019 - mdpi.com
Recurrent pregnancy loss (RPL) represents an unresolved problem for contemporary
gynecology and obstetrics. In fact, it is not only a relevant complication of pregnancy, but is …

[HTML][HTML] Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

ES Lucas, P Vrljicak, J Muter… - Communications …, 2020 - nature.com
During the implantation window, the endometrium becomes poised to transition to a
pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC) …

[HTML][HTML] The update immune-regulatory role of pro-and anti-inflammatory cytokines in recurrent pregnancy losses

X Yang, Y Tian, L Zheng, T Luu… - International journal of …, 2022 - mdpi.com
Recurrent pregnancy losses (RPL) is a common reproductive disorder with various
underlying etiologies. In recent years, rapid progress has been made in exploring the …

[HTML][HTML] Maternal selection of human embryos in early gestation: insights from recurrent miscarriage

JJ Brosens, PR Bennett, VM Abrahams… - Seminars in cell & …, 2022 - Elsevier
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally
diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate …

[HTML][HTML] Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation

CS Kong, AA Ordoñez, S Turner, T Tremaine… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Decidualizing endometrial stromal cells (EnSC) critically determine the maternal response to
an implanting conceptus, triggering either menstruation‐like disposal of low‐fitness embryos …

An altered microbiota in the lower and upper female reproductive tract of women with recurrent spontaneous abortion

FT Liu, S Yang, Z Yang, P Zhou, T Peng… - Microbiology …, 2022 - Am Soc Microbiol
Recurrent spontaneous abortion (RSA) is a complex multifactorial disease. Recently, the
microbiota of the female reproductive tract, as an emerging factor in RSA, has gradually …

[HTML][HTML] Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells

ON Mann, CS Kong, ES Lucas, JJ Brosens… - Scientific reports, 2022 - nature.com
The human luteinising hormone choriogonadotropin receptor (LHCGR) is a G-protein
coupled receptor activated by both human chorionic gonadotropin (hCG) and luteinizing …

Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium

M Diniz-da-Costa, CS Kong, KJ Fishwick… - Stem Cells, 2021 - academic.oup.com
Pregnancy depends on the wholesale transformation of the endometrium, a process driven
by differentiation of endometrial stromal cells (EnSC) into specialist decidual cells. Upon …

[HTML][HTML] The role of decidual subpopulations in implantation, menstruation and miscarriage

J Muter, CS Kong, JJ Brosens - Frontiers in reproductive health, 2021 - frontiersin.org
In each menstrual cycle, the endometrium becomes receptive to embryo implantation while
preparing for tissue breakdown and repair. Both pregnancy and menstruation are …