Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective
Y Zhang, X Liang, X Bao, W Xiao, G Chen - European Journal of Medicinal …, 2022 - Elsevier
Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …
involved in innate immunity and mediates inflammatory responses by recognizing …
Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
Novel quinoline-based derivatives: A new class of PDE4B inhibitors for adjuvant-induced arthritis
S Xing, W Fan, J Chen, J Du, T Liu, S Dong… - European Journal of …, 2022 - Elsevier
A total of 31 quinoline-based derivatives were designed and synthesized to develop novel
anti-inflammatory drugs. After the toxicity of synthetic compounds to RAW264. 7 cells were …
anti-inflammatory drugs. After the toxicity of synthetic compounds to RAW264. 7 cells were …
Investigation on the mechanism of 2, 3, 4′, 5-Tetrahydroxystilbene 2-oD-glucoside in the treatment of inflammation based on network pharmacology
L Sun, B Wang, T Sun, F Zhou, B Zhu, C Li… - Computers in biology …, 2022 - Elsevier
Background Inflammation is the pathogenesis of various chronic diseases plaguing clinic for
years. Fallopia multiflora (Thunb.) is a traditional Chinese herbal medicine with a long …
years. Fallopia multiflora (Thunb.) is a traditional Chinese herbal medicine with a long …
Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease
S Dong, J Xia, F Wang, L Yang, S Xing, J Du… - European Journal of …, 2024 - Elsevier
A series of deoxyvasicinone derivatives with benzenesulfonamide substituents were
designed and synthesized to find a multifunctional anti-Alzheimer's disease (AD) drug. The …
designed and synthesized to find a multifunctional anti-Alzheimer's disease (AD) drug. The …
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation
T Zhang, S Xing, J Du, J Xia, S Dong, Z Li, Z Liu… - Bioorganic …, 2023 - Elsevier
In this study, a receptor structure-based virtual screening strategy was constructed using a
computer-aided drug design. First, the compounds were filtered based on the Lipinski …
computer-aided drug design. First, the compounds were filtered based on the Lipinski …
[HTML][HTML] Design, synthesis, and antiviral activities evaluation of novel quinazoline derivatives containing sulfonamide moiety
Y Deng, S Yin, X Jing, Y Zheng - Heterocyclic Communications, 2023 - degruyter.com
A series of novel quinazoline derivatives bearing sulfonamide moiety was designed and
synthesized, and their structure were characterized by 1H NMR, 13C NMR, and HRMS …
synthesized, and their structure were characterized by 1H NMR, 13C NMR, and HRMS …
[PDF][PDF] Anti-inflammatory effect of glycyrrhetinic acid in IL-1β-induced SW982 cells and adjuvant-induced arthritis
Y Song, X Xing, J Shen, G Chen, L Zhao, L Tian, J Ying… - Heliyon, 2023 - cell.com
Influences of Glycyrrhetinic acid on expression of inflammatory factors in interleukin (IL)-1β-
induced SW982 cells and its anti-inflammatory effects were discussed in this study. MTT …
induced SW982 cells and its anti-inflammatory effects were discussed in this study. MTT …
[HTML][HTML] Protective effects of (4-(1, 2, 4-oxadiazol-5-yl) phenyl)-2-aminoacetamide derivatives to adjuvant-induced arthritis rats by regulating the NF-κB signaling …
T Liu, Y Zhu, S Chen, J Du, S Xing, S Dong, J Xia… - …, 2022 - Springer
Abstract A series of (4-(1, 2, 4-oxadiazol-5-yl) phenyl)-2-aminoacetamide derivatives
showed good anti-neuroinflammation in our previous study. Some studies have proven that …
showed good anti-neuroinflammation in our previous study. Some studies have proven that …