GAS41 modulates ferroptosis by anchoring NRF2 on chromatin
YEATS domain-containing protein GAS41 is a histone reader and oncogene. Here, through
genome-wide CRISPR-Cas9 screenings, we identify GAS41 as a repressor of ferroptosis …
genome-wide CRISPR-Cas9 screenings, we identify GAS41 as a repressor of ferroptosis …
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Q Shi, C Xue, Y Zeng, X Yuan, Q Chu, S Jiang… - … and Targeted Therapy, 2024 - nature.com
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
[HTML][HTML] Contribution of histone variants to aneuploidy: a cancer perspective
D Ragusa, P Vagnarelli - Frontiers in Genetics, 2023 - frontiersin.org
Histone variants, which generally differ in few amino acid residues, can replace core
histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to …
histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to …
Discovering potential inhibitors of the YEATS domain of YEATS2 through virtual screening, molecular optimization and molecular dynamics simulations
X Wang, G Cheng, J Zhao, P Gao, H Mao… - New Journal of …, 2023 - pubs.rsc.org
YEATS domains have been recently identified as novel readers of histone lysine acylation.
Increasing evidence has revealed that dysregulated interactions between YEATS domains …
Increasing evidence has revealed that dysregulated interactions between YEATS domains …
[HTML][HTML] Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4
Q Xian, Y Song, C Gui, Y Zhou - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
As a novel oncogene, the role of YEATS domain-containing protein 4 (YEATS4) in the
occurrence, development, and treatment of tumors is now beginning to be appreciated …
occurrence, development, and treatment of tumors is now beginning to be appreciated …
Unveiling the role of GAS41 in cancer progression
K Ji, L Li, H Liu, Y Shen, J Jiang, M Zhang… - Cancer Cell …, 2023 - Springer
GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer
development. It serves as a highly promising epigenetic reader, facilitating precise …
development. It serves as a highly promising epigenetic reader, facilitating precise …
High N6‐methyladenosine‐activated TCEAL8 mRNA is a novel pancreatic cancer marker
Abstract N6‐methyladenosine (m6A) is an RNA modification involved in RNA processing
and widely found in transcripts. In cancer cells, m6A is upregulated, contributing to their …
and widely found in transcripts. In cancer cells, m6A is upregulated, contributing to their …
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis
L Yang, Y Ruan, H Xu - BMC cancer, 2024 - Springer
In recent years, there has been an increase in the incidence and mortality rates of prostate
cancer (PCa). However, the specific molecular mechanisms underlying its occurrence and …
cancer (PCa). However, the specific molecular mechanisms underlying its occurrence and …
[HTML][HTML] Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A. Z. 1-E2F1 pathway
S Xiang, L Jian, H Zeng, H Wu, B Ge, P Zhang… - Biochemical …, 2023 - Elsevier
Cutaneous melanoma is one of the most prevalent tumors, and it is still a huge challenge in
the current clinical treatment. Isoliquiritigenin (ISL), which is isolated from Glycyrrhiza …
the current clinical treatment. Isoliquiritigenin (ISL), which is isolated from Glycyrrhiza …
[HTML][HTML] 巴豆酰化修饰在恶性肿瘤中的研究进展
刘芳远， 苏丽娅 - 肿瘤防治研究, 2023 - html.rhhz.net
作为一种新发现的翻译后修饰, 巴豆酰化修饰在组蛋白和非组蛋白中均被证实大量存在,
并参与了多种疾病和生物学过程的调控. 随着高分辨率质谱检测技术的发展 …
并参与了多种疾病和生物学过程的调控. 随着高分辨率质谱检测技术的发展 …