Osteogenesis imperfecta, or" brittle bone disease," is a type I collagen-related condition
associated with osteoporosis and increased risk of bone fractures. Using a combination of …

Paget's disease of bone (PDB) is a common disorder with a strong genetic component
characterized by focal increases in bone turnover, which in some cases is caused by …

Osteoporosis is a devastating disease with an essential genetic component. GWAS have
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …

This chapter is devoted to the role of genetic variation and gene-exercise interactions in the
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Breast cancer is the most common female cancer, affecting approximately one in eight
women during their life-time. Besides environmental triggers and hormones, inherited …

Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Background: Osteoporosis is a highly heritable trait. Many candidate genes have been
proposed as being involved in regulating bone mineral density (BMD). Few of these findings …

Pubertal maturation plays a fundamental role in bone acquisition. In retrospective
epidemiological surveys in pre-and postmenopausal women, relatively later menarcheal …

Recent studies have revealed the existence of numerous contact sites between the
endoplasmic reticulum (ER) and endosomes in mammalian cells. Such contacts increase …