The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …

Osteoporosis is a multifactorial disease influenced by genetic and environmental factors,
which contributes to an increased risk of bone fracture, but early diagnosis of this disease …

To identify genetic loci influencing bone accrual, we performed a genome-wide association
scan for total-body bone mineral density (TB-BMD) variation in 2,660 children of different …

Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different
relative contributions of genetic and environmental influences. To quantify the degree to …

Modifications in maternal nutrition during pregnancy can significantly disrupt fetal growth
and subsequent post-natal health and survival. This study investigated the effects of …

Aiming to identify novel genetic variants and to confirm previously identified genetic variants
associated with bone mineral density (BMD), we conducted a three-stage genome-wide …

It is becoming increasingly apparent that the risk of developing osteoporosis is accrued
throughout the entire lifecourse, even from as early as conception. Thus early growth is …

Diabetes and osteoporosis are both common diseases with increasing prevalences in the
aging population. There is increasing evidence corroborating an association between …

More than 300 million years ago, vertebrates emerged from the vast oceans to conquer
gravity and the dry land. With this transition, new adaptations occurred that included …