Osteoporosis is a systemic disease that results in loss of bone density and increased
fracture risk, particularly in the vertebrae and the hip. This condition and associated …

The costs of comprehensively genotyping human subjects have fallen to the point where
major funding bodies, even in the social sciences, are beginning to incorporate genetic and …

Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing
osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly …

Genome-wide association studies (GWASs) have reproducibly associated variants within
intergenic regions of 1p36. 12 locus with osteoporosis, but the functional roles underlying …

The musculoskeletal system is a complex organ comprised of the skeletal bones, skeletal
muscles, tendons, ligaments, cartilage, joints, and other connective tissue that physically …

Osteoporosis is a metabolic bone disease with dysregulated coupling between bone
resorption and bone formation, which results in decreased bone mineral density. The …

To identify genetic variants associated with head circumference in infancy, we performed a
meta-analysis of seven genome-wide association studies (GWAS)(N= 10,768 individuals of …

The Wnt signaling pathway plays key roles in differentiation and development and
alterations in this signaling pathway are causally associated with numerous human …

Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …

Epigenetics refers to the study of mechanisms able to influence gene expression in a stable
and potentially heritable manner without altering the DNA sequence. These mechanisms …