Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

Although several lines of evidence have shown a role of the nitric oxide/cyclic guanosine
monophosphate signaling pathway in the nociceptive mechanism, the exact role of the …

Nitric oxide (NO) plays pivotal roles in controlling physiological functions, participates in
pathophysiological intervention, and is involved in mechanisms underlying beneficial or …

Recent evidence indicates that sildenafil may exert some central effects through
enhancement of nitric oxide (NO)‐mediated effects. NO is known to have modulatory effects …

The involvement of K+ channels in the antinociceptive action of diclofenac was assessed in
the formalin test. Local administration of diclofenac produced a dose-dependent …

Background: Since its approval by the US Food and Drug Administration in March 1998,
sildenafil citrate has been used by millions of men for the treatment of erectile dysfunction …

G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR)
that can be activated by kynurenic acid at high micromolar concentrations. A previously …

Abstract Rapid (premature) ejaculation (RE) is a very common sexual disorder. This
condition may be primary or secondary to underlying disease. Control of RE has been …

The possible participation of the nitric oxide (NO)-cyclic GMP-protein kinase G (PKG)-K+
channel pathway on melatonin-induced local antinociception was assessed during the …