Clinical pharmacology in the geriatric patient

SN Hilmer, AJ McLachlan… - Fundamental & clinical …, 2007 - Wiley Online Library
Geriatric patients are a subset of older people with multiple comorbidities that usually have
significant functional implications. Geriatric patients have impaired homeostasis and wide …

The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials

J Birns, R Morris, N Donaldson, L Kalra - Journal of hypertension, 2006 - journals.lww.com
Objective To review systematically and synthesize quantitatively the evidence from
completed randomized, controlled trials of blood pressure reduction on cognitive …

Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons

LB Hoffman, J Schmeidler, GT Lesser, MS Beeri… - Neurology, 2009 - AAN Enterprises
Objective: To test the hypothesis that use of antihypertensive medication is associated with
lower Alzheimer disease (AD) neuropathology. Methods: This was a postmortem study of …

Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health

HIL Jacobs, EC Leritz, VJ Williams… - Human brain …, 2013 - Wiley Online Library
Cerebral white matter damage is not only a commonly reported consequence of healthy
aging, but is also associated with cognitive decline and dementia. The aetiology of this …

Hypertension is associated with cognitive decline in elderly people at high risk for dementia

M Wysocki, X Luo, J Schmeidler, K Dahlman… - The American journal of …, 2012 - Elsevier
Cardiovascular risk factors including hypertension (HTN) have been shown to increase the
risk of Alzheimer disease. The current study investigated whether individuals with HTN are …

The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent

HIL Jacobs, PJ Visser, MPJ Van Boxtel, GB Frisoni… - Neurobiology of …, 2012 - Elsevier
White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been
associated with impaired executive functioning, although contradictory findings have been …

The aging mind: vascular health in normal cognitive aging

JRL Warsch, CB Wright - Journal of the American Geriatrics …, 2010 - Wiley Online Library
In spite of the breakneck speed at which understanding of the biological basis of the aging
process has evolved, the important determinants of aging and longevity have yet to be …

[HTML][HTML] Sex and age differences in the association of blood pressure and hypertension with cognitive function in the elderly: the Rancho Bernardo Study

D Kritz-Silverstein, GA Laughlin… - The journal of …, 2017 - ncbi.nlm.nih.gov
Sex and Age Differences in the Association of Blood Pressure and Hypertension with
Cognitive Function in the Elderly: The Rancho Bernardo Study - PMC Back to Top Skip to …

Program of rehabilitative exercise and education to avert vascular events after non-disabling stroke or transient ischemic attack (PREVENT Trial): a multi-centred …

M MacKay-Lyons, G Gubitz, N Giacomantonio… - BMC neurology, 2010 - Springer
Background Despite lack of outward signs, most individuals after non-disabling stroke (NDS)
and transient ischemic attack (TIA) have significant cardiovascular and cerebrovascular …

Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE …

QY Li, HY Hu, GW Zhang, H Hu, YN Ou… - Alzheimer's Research & …, 2024 - Springer
Background Cardiometabolic multimorbidity is associated with an increased risk of
dementia, but the pathogenic mechanisms linking them remain largely undefined. We aimed …