The Importance of STK11/LKB1 Assessment in Non-Small Cell Lung Carcinomas

B Mograbi, S Heeke, P Hofman - Diagnostics, 2021 - mdpi.com
Despite the recent implementation of immunotherapy as a single treatment or in combination
with chemotherapy for first-line treatment of advanced non-small cell lung cancer (NSCLC) …

[HTML][HTML] The challenges of evaluating predictive biomarkers using small biopsy tissue samples and liquid biopsies from non-small cell lung cancer patients

P Hofman - Journal of thoracic disease, 2019 - ncbi.nlm.nih.gov
The list of theranostic biomarkers for the care of patients with advanced stage or metastatic
non-small cell lung cancer has lengthened considerably these last few years. Moreover, the …

Setting up an ultra-fast next-generation sequencing approach as reflex testing at diagnosis of non-squamous non-small cell lung cancer; experience of a single center …

M Ilié, V Hofman, C Bontoux, S Heeke… - Cancers, 2022 - mdpi.com
Simple Summary Due to the increase of molecular biomarkers to be characterized to tailor
therapeutic strategies for non-squamous non-small cell lung carcinoma (NS-NSCLC), it is …

Current status of ctDNA in precision oncology for hepatocellular carcinoma

Y Li, Y Zheng, L Wu, J Li, J Ji, Q Yu, W Dai… - Journal of Experimental …, 2021 - Springer
The conventional method used to obtain a tumor biopsy for hepatocellular carcinoma (HCC)
is invasive and does not evaluate dynamic cancer progression or assess tumor …

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

N Costa-Borges, K Spath, I Miguel-Escalada, E Mestres… - Elife, 2020 - elifesciences.org
The developmental potential of early embryos is mainly dictated by the quality of the oocyte.
Here, we explore the utility of the maternal spindle transfer (MST) technique as a …

FFPE-based NGS approaches into clinical practice: the limits of glory from a pathologist viewpoint

F Cappello, V Angerilli, G Munari, C Ceccon… - Journal of Personalized …, 2022 - mdpi.com
The introduction of next-generation sequencing (NGS) in the molecular diagnostic
armamentarium is deeply changing pathology practice and laboratory frameworks. NGS …

Modulating tumor microenvironment: A review on STK11 immune properties and predictive vs prognostic role for non-small-cell lung cancer immunotherapy

G Mazzaschi, A Leonetti, R Minari, L Gnetti… - … Treatment Options in …, 2021 - Springer
Opinion Statement The quest for immunotherapy (IT) biomarkers is an element of highest
clinical interest in both solid and hematologic tumors. In non-small-cell lung cancer (NSCLC) …

Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience …

S Lassalle, V Hofman, S Heeke, J Benzaquen, E Long… - Cancers, 2020 - mdpi.com
Background: Assessment of actionable EGFR mutations is mandatory for treatment-naïve
advanced or metastatic non-squamous lung carcinoma (NSLC), but the results need to be …

Prospective evaluation of NGS-based liquid biopsy in untreated late stage non-squamous lung carcinoma in a single institution

S Heeke, V Hofman, M Ilié, M Allegra… - Journal of translational …, 2020 - Springer
Background NGS from plasma samples in non-squamous cell lung carcinoma (NSCC) can
aid in the detection of actionable genomic alterations. However, the absolute clinical value …

DNAshell protects DNA stored at room temperature for downstream next-generation sequencing studies

K Washetine, S Heeke, C Ribeyre… - Biopreservation and …, 2019 - liebertpub.com
Up to the present time, tissue samples are mostly stored fixed in formalin and embedded in
paraffin or as frozen samples. However, the direct extraction and storage of DNA is also …