Background Redirecting glucose from skeletal muscle and adipose tissue, likely benefits the
tumor's energy demand to support tumor growth, as cancer patients with type 2 diabetes …

Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose
metabolism is of concern, as it is associated with higher cancer recurrence rates and …

Available data suggest that cannabidiol (CBD) may ameliorate symptoms of insulin
resistance by modulating the sphingolipid concentrations in particular organs. However, it is …

Metabolic dysfunction and insulin resistance are emerging as hallmarks of cancer and
cachexia, and impair cancer prognosis. Yet, the molecular mechanisms underlying impaired …

The glucose transporter GLUT4 is integral for optimal skeletal muscle performance during
exercise, as well as for metabolic health. Physiological regulation of GLUT4 translocation …

Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver
disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in …

Context Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually
associated with aging) shares pathophysiological mechanisms with polycystic ovary …

Objectives Obesity is a multifactorial condition associated with metabolic alterations that can
be aggravated during female aging. Calorie restriction via intermittent fasting (IF) diets may …

Obesity is associated with excess body fat accumulation that can cause hyperglycemia and
reduce skeletal muscle function and strength, which characterize the development of …

Insulin action in adipose tissue is crucial for whole-body glucose homeostasis, with insulin
resistance being a major risk factor for metabolic diseases such as type 2 diabetes. Recent …