[HTML][HTML] Skeletal muscle myosin heavy chain expression and 3D capillary network changes in streptozotocin-induced diabetic female mice

N Umek, L Pušnik, CK Ugwoke, Ž Šink… - Biomolecules and …, 2024 - ncbi.nlm.nih.gov
It is not well-understood how type 1 diabetes (T1DM) affects skeletal muscle histological
phenotype, particularly capillarisation. This study aimed to analyze skeletal muscle myosin …

The expression of NFAT family genes in subcutaneous adipose tissue before and after weight loss in obese individuals

M Danowska, M Stefanowicz, M Strączkowski - Nutrition, Metabolism and …, 2024 - Elsevier
Abstract Background and Aims Adipose tissue (AT) serves as a vital energy storage site and
plays a pivotal role in metabolic regulation, exhibiting a high response to insulin. Impairment …

Hyperinsulinemia, obesity, and diabetes mellitus

P SS - International Journal of Diabetes in Developing …, 2023 - Springer
Insulin clearance is an important piece of the puzzle that needs to be incorporated to gain an
understanding of obesity and type 2 diabetes mellitus (T2DM). Recently, Gastaldelli and …

Deletion of LDLRAP1 induces atherosclerotic plaque formation, insulin resistance, and dysregulated insulin response in adipose tissue

T Leigh, T Kawai, K Preston, S Kelemen… - The American Journal of …, 2022 - Elsevier
Dyslipidemia, vascular inflammation, obesity, and insulin resistance often overlap and
exacerbate each other. Mutations in low density lipoprotein receptor adaptor protein-1 …

Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action

EJ Needham, JR Hingst, JD Onslev, A Diaz-Vegas… - medRxiv, 2024 - medrxiv.org
Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the
precise mechanisms is incomplete. Here, we investigate how insulin resistance alters …

[HTML][HTML] Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes

P Dipta, A Sarsenbayeva, M Shmuel, F Forno… - Comprehensive …, 2021 - Elsevier
Abstract Objective Olanzapine and Aripiprazole are widely used second-generation
antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic …

Activités physiques, sédentarité, comorbidités et arthrose

B Fouquet, P Jaume-Guichard - Revue du Rhumatisme Monographies, 2021 - Elsevier
Osteoarthritis (OA) is a global disease of all the structures of a joint. It is heterogeneous due
to the different OA phenotypes. If biomechanical constraints with multiples factors can cause …

[HTML][HTML] Prevalence of Steroid-Induced Hyperglycemia in King Abdulaziz Specialist Hospital, Taif City, Saudi Arabia

JF Sarriyah, AS Alghamdi, NM Al-Otaibi… - Cureus, 2024 - ncbi.nlm.nih.gov
Methods A retrospective study was conducted among 245 patients. The inclusion criteria
were patients undergoing steroid therapy and admitted to a single tertiary care hospital due …

Microcystin‐LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line

T Ma, N Cao, K Chen, H Wang, L Xu… - Environmental …, 2020 - Wiley Online Library
Abstract Microcystin‐LR (MC‐LR) is a widely produced monocyclic heptapeptides in
eutrophication waterbodies. MC‐LR can induce various toxic effects in different cells. Our …

[HTML][HTML] Consequences of insulin resistance long term in the body and its association with the development of chronic diseases

SM Al-Badrani, NS Al-Sowayan - Journal of Biosciences and Medicines, 2022 - scirp.org
Insulin resistance (IR) has become more common in recent years, and it has been related to
a number of metabolic disturbances such as obesity, non-alcoholic fatty liver disease …