The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

The aggregation of proteins is tightly controlled in living systems, and misfolded proteins are
normally removed before aggregation of the misfolded protein can occur. But for reasons not …

This tutorial review presents descriptions of two amyloidogenic proteins, amyloid-β (Aβ)
peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated …

Islet amyloid polypeptide (IAPP) has been identified as the major constituent of the
pancreatic amyloid of non-insulin-dependent diabetes mellitus (NIDDM) and is also present …

The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid
deposits associated with type 2 diabetes. The polypeptide lacks a well-defined structure in …

Islet amyloid polypeptide (IAPP) contributes to the pathogenesis of type II diabetes by
depositing as cytotoxic amyloid fibers in the endocrine pancreas. Fiber formation occurs with …