Dual bronchodilation for the treatment of COPD: from bench to bedside

M Cazzola, C Page, P Rogliani… - British Journal of …, 2022 - Wiley Online Library
Because there is a solid pharmacological rationale based on positive interactions between
long‐acting muscarinic receptor antagonists (LAMAs) and long‐acting β‐agonists (LABAs) …

Optimizing de-escalation of inhaled corticosteroids in COPD: a systematic review of real-world findings

P Rogliani, BL Ritondo, M Gabriele… - Expert Review of …, 2020 - Taylor & Francis
Introduction To date, there is solid evidence from randomized controlled trials (RCTs)
supporting the rationale for withdrawal from inhaled corticosteroids (ICSs) in most patients …

The airways' mechanical stress in lung disease: implications for COPD pathophysiology and treatment evaluation

P Santus, M Pecchiari, F Tursi, V Valenti… - Canadian …, 2019 - Wiley Online Library
The airway epithelium stretches and relaxes during the normal respiratory cycle, and
hyperventilation exaggerates this effect, resulting in changes in lung physiology. In fact …

Overuse of long-acting β2-agonist/inhaled corticosteroids in patients with chronic obstructive pulmonary disease: time to rethink prescribing patterns

SA Brunton, DK Hogarth - Postgraduate Medicine, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality globally. In the major revision of the Global Initiative for Chronic Obstructive …

[HTML][HTML] Indacaterol/glycopyrronium affects lung function and cardiovascular events in patients with chronic obstructive pulmonary diseases: A meta-analysis

Q Zhang, H Zhang, J Wang, Z Ruan, Y Dai, Z Xia, Q Lv - Heart & Lung, 2021 - Elsevier
Background Bronchodilators are the cornerstone for treating patients with chronic
obstructive pulmonary diseases (COPD), although some studies have shown that dual …

Pharmacotherapy of LAMA/LABA inhaled therapy combinations for chronic obstructive pulmonary disease: a clinical overview

MG Matera, B Rinaldi, C Belardo… - Expert Review of Clinical …, 2022 - Taylor & Francis
Introduction Long-acting muscarinic receptor antagonist (LAMA)/β2-agonist (LABA)
combinations represent a significant improvement in the treatment of chronic obstructive …

[HTML][HTML] Implementation of a targeted inhaled corticosteroid de-escalation process in patients with chronic obstructive pulmonary disease in the primary care setting

NM Hahn, MW Nagy - Innovations in Pharmacy, 2022 - ncbi.nlm.nih.gov
Purpose: To evaluate the feasibility and success of a pharmacist-led, targeted inhaled
corticosteroid (ICS) de-escalation process in patients with chronic obstructive pulmonary …

Revisión narrativa de la terapia inhalatoria en la EPOC

MV Martínez, EC Manuel, AL Aguilar-Shea - Medicina de Familia …, 2024 - Elsevier
La base del tratamiento de mantenimiento de la EPOC son los broncodilatadores de acción
larga y los corticoides inhalados. Frente a las modificaciones recientes en las guías de …

Clinical development and research applications of the chronic obstructive pulmonary disease assessment test

H Müllerová, MT Dransfield, B Thomashow… - American Journal of …, 2020 - atsjournals.org
Despite available therapies for chronic obstructive pulmonary disease (COPD), significant
unmet treatment needs remain because most patients with COPD experience chronic …

[HTML][HTML] Direct switch from tiotropium to indacaterol/glycopyrronium in chronic obstructive pulmonary disease patients in Korea

SH Lee, CK Rhee, K Yoo, JW Park… - Tuberculosis and …, 2021 - ncbi.nlm.nih.gov
Background Many chronic obstructive pulmonary disease (COPD) patients receiving
monotherapy continue to experience symptoms, exacerbations and poor quality of life. This …