Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered
frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1 …

Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

Epigenetic modifications work in concert with genetic mechanisms to regulate transcriptional
activity in normal tissues and are often dysregulated in disease. Although they are …

In contrast to studies on class I histone deacetylase (HDAC) inhibitors, the elucidation of the
molecular mechanisms and therapeutic potential of class IIa HDACs (HDAC4, HDAC5 …

Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in
the colon. In the last decade, multiple beneficial effects of butyrate at intestinal and …

Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential
as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin …

Histone deacetylase inhibitors (HDACi) developed as anti-cancer agents have a high
degree of selectivity for killing cancer cells. HDACi induce acetylation of histones and …