Microglia polarization from M1 to M2 in neurodegenerative diseases

S Guo, H Wang, Y Yin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Neuroinflammation and depression: A review

R Troubat, P Barone, S Leman… - European journal of …, 2021 - Wiley Online Library
Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease

D Kaur, V Sharma, R Deshmukh - Inflammopharmacology, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

[HTML][HTML] Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

WY Wang, MS Tan, JT Yu, L Tan - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is
characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

Pathological mechanisms in progressive multiple sclerosis

DH Mahad, BD Trapp, H Lassmann - The Lancet Neurology, 2015 - thelancet.com
A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation

D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

Progressive multiple sclerosis: pathology and pathogenesis

H Lassmann, J Van Horssen, D Mahad - Nature Reviews Neurology, 2012 - nature.com
Major progress has been made during the past three decades in understanding the
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant …

P Kopschina Feltes, J Doorduin… - Journal of …, 2017 - journals.sagepub.com
Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …

Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease

BS Thawkar, G Kaur - Journal of neuroimmunology, 2019 - Elsevier
Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …