Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum
which behaves malignantly and confers a poor prognosis despite indolent growth patterns …

Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …

Chordomas are rare bone tumors with no approved therapy. These tumors express several
activated tyrosine kinase receptors, which prompted attempts to treat patients with tyrosine …

Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic
options. We undertook a focused compound screen (FCS) against 1097 compounds on …

Introduction and objective: Despite the improvements in management and treatment of
chordomas over time, the risk of disease recurrence remains high. Consequently, there is a …

Chordomas are primary bone tumors that arise in the cranial base, mobile spine, and
sacrococcygeal region, affecting patients of all ages. Currently, there are no approved …

Recent molecular investigations of chordoma show common expression of various receptor
tyrosine kinases and activation of downstream signaling pathways contributing to tumor …

Chordoma is a rare, orphan cancer arising from embryonal precursors of bone. Surgery and
radiotherapy (RT) provide excellent local control, often at the price of significant morbidity …

The success of the endoscopic endonasal approach (EEA) to surgically manage clival
chordomas (CC) relies on robust repair methods to reduce complications, such as …

Background Chordoma is a rare, slow growing and locally aggressive mesenchymal
neoplasm with uncommon distant metastases. It is a chemo-resistant disease with surgery …