Abstract Nowadays, Artificial Intelligence (AI) and machine learning (ML) have successfully
provided automated solutions to numerous real-world problems. Healthcare is one of the …

The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …

This study underlines the importance of treadmill exercise in reducing α-synuclein (α-syn)
spreading in the A53T brain and protecting nigral dopaminergic neurons. Preformed α-syn …

Background The current genome-wide association study (GWAS) of Lewy body dementia
(LBD) suffers from low power due to a limited sample size. In addition, the genetic …

Background: Dementia with Lewy bodies (DLB) is a neurodegenerative disease where
synaptic loss and reduced synaptic integrity are important neuropathological substrates …

Inflammation and alterations in essential protein structures in the brain might also change
the cellular distribution in the cerebrospinal fluid (CSF). Using flow cytometry, we analyzed …

Extrapyramidal movement disorders include hypokinetic rigid and hyperkinetic or mixed
forms, most of them originating from dysfunction of the basal ganglia (BG) and their …

Introduction As the identification of Lewy body dementia (LBD) is often confirmed
postmortem, there is a paucity of evidence on the progression of disease antemortem. This …

Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct
balance between protein synthesis, folding and degradation. Proteostasis is essential for …

Abstract Lewy Body Dementia is the second most frequent neurodegenerative illness
proven to cause dementia, after Alzheimer's disease (AD). It is believed to be vastly …