Although dysregulation of mitochondrial dynamics has been linked to cellular senescence,
which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 …

CD38 is the main enzyme for nicotinamide adenine dinucleotide (NAD) degradation in
mammalian cells. Decreased NAD levels are closely related to metabolic syndromes and …

Cells respond to stress by activating a variety of defense signaling pathways, including cell
survival and cell death pathways. Although cell survival signaling helps the cell to recover …

Backgrounds and aims Leucine, isoleucine, and valine are diet derived and essential amino
acids that are termed branched-chain amino acids (BCAA). BCAA are widely used as dietary …

Introduction Vascular smooth muscle cell (VSMC) senescence in the vasculature results in
vascular aging as well as age-related diseases, while metformin improves the inflamm …

Background: Aging has often been linked to age-related vascular disorders. The elucidation
of the putative genes and pathways underlying vascular aging likely provides useful insights …

Atherosclerosis constitutes a major risk factor for cardiovascular diseases, the leading cause
of morbidity and mortality worldwide. This slowly progressing, chronic inflammatory disorder …

Autonomic dysfunction is a clinical hallmark of infection caused by SARS‐CoV‐2, but the
underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important …

e138 Arterioscler Thromb Vasc Biol August 2018 major difference between these 2 studies
is Gao et al's10 focus on long-term effects of variances in normal levels of sodium levels …

Vascular aging is defined as organic and functional changes in blood vessels, in which
decline in autophagy levels, DNA damage, MicroRNA (miRNA), oxidative stress, sirtuin, and …