Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2)
in suppressing atherosclerotic plaque progression and instability. However, the underlying …

Objective Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide; yet, the pathogenesis of the disorder is not completely understood. The nicotinic …

Vascular aging plays a pivotal role in the morbidity and mortality of elderly people. Decrease
in autophagy leads to acceleration of vascular aging, while increase in autophagy leads to …

Objective—Smooth muscle (SM) 22α, an actin-binding protein, displays an upregulated
expression as a marker during cellular senescence. However, the causal relationship …

Smooth muscle cell (SMC) phenotypic switch from a quiescent 'contractile'phenotype to a
dedifferentiated and proliferative state underlies the development of cardiovascular …

Cardiovascular disease (CVD) is a prevalent issue in the global aging population.
Premature vascular aging such as elevated arterial stiffness appears to be a major risk factor …

Many different receptors and ion channels that regulate ion currents are involved in the
control of the cardiovascular system (CVS). The functioning of the CVS occurs with the …

Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described
symptom of Alzheimer's disease (AD). However, accumulating evidence suggests …

Alginate oligosaccharide (AOS) may delay aging by decreasing oxidative stress, but the
effects on vascular aging remain unclear. Here, we evaluate the effect of AOS on vascular …

More than a century after the discovery of nicotinamide adenine dinucleotide (NAD+), our
understanding of the molecule's role in the biology of ageing continues to evolve. As a …