Gap-junction communication in chemical carcinogenesis

RJ Ruch, JE Trosko - Drug metabolism reviews, 2001 - Taylor & Francis
In a recent review article,“Risk Assessment for Possible Carcinogens: A Critical Look”(1), Dr.
Emmanuel Farber states,“There is a developing speculation that agents or circumstances …

Role of gap junctions in lung neoplasia

RJ Ruch, K Cesen-Cummings… - Experimental lung …, 1998 - Taylor & Francis
Reduced gap junctional intercellular communication (GJIC) has been noted in many types of
neoplastic cells and may contribute to the neoplastic phenotype. This study assessed GJIC …

Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells

ZQ Zhang, Y Hu, BJ Wang, ZX Lin, CCG Naus… - …, 2004 - academic.oup.com
The dysfunction of homologous and/or heterologous gap junctional intercellular
communication (GJIC) has been implicated in tumorigenesis of many kinds of cells. Here we …

Neoplastic phenotype of gap‐junctional intercellular communication–deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32

RS Rae, PP Mehta, CC Chang… - … in cooperation with …, 1998 - Wiley Online Library
Gap‐junctional intercellular communication (GJIC) is involved in cellular growth control and
is often reduced in neoplastic cells. In this study, four GJIC‐deficient rat liver epithelial cell …

Oxidative stress, signal transduction, and intercellular communication in radiation carcinogenesis

JE Trosko, T Inoue - Stem Cells, 1997 - Wiley Online Library
During the evolution of multicellular organisms, survival in an aerobic environment came
about by adaptive responses, both to the endogenous oxidative metabolism within the cells …

ACCELERATED PAPER: Inhibition of gap junctional intercellular communication by barbiturates in long-term primary cultured rat hepatocytes is correlated with liver …

P Ren, RJ Ruch - Carcinogenesis, 1996 - academic.oup.com
Rodent liver tumor formation can be promoted by certain barbiturates and this may involve
their ability to inhibit hepatocyte gap junctional intercellular communication (GJIC). In order …

Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids.

HL de Feijter-Rupp, T Hayashi, GH Kalimi… - …, 1998 - academic.oup.com
Gap junctional intercellular communication (GJIC) has been implicated in homeostasis,
development, differentiation, wound healing or regeneration and adaptive responses of …

Pathological significance of connexin 26 expression in colorectal adenocarcinoma

R Hong, SC Lim - Oncology reports, 2008 - spandidos-publications.com
This study was conducted to determine the level of expression and cellular localization of
connexin 26 (Cx26) and the expression of p53 in colorectal adenocarcinoma as well as their …

Impaired wound healing compositions and treatments

DL Becker, CR Green, BJ Duft - US Patent 8,063,023, 2011 - Google Patents
US8063023B2 - Impaired wound healing compositions and treatments - Google Patents
US8063023B2 - Impaired wound healing compositions and treatments - Google Patents …

Role of gap junctions in cellular growth control and neoplasia: Evidence and mechanisms

RJ Ruch - Current topics in membranes, 1999 - Elsevier
Publisher Summary This chapter focuses on the role of gap junctional intercellular
communication (GJIC) in cellular growth control and neoplasia and considers the large body …