Recombinant F (ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft.

W Debinski, I Pastan - Clinical cancer research: an official journal of the …, 1995 - AACR
We have previously made a Mr 195,000 immunotoxin (IT) composed of mAb C242 coupled
to Pseudomonas exotoxin A. This IT inhibited growth but did not cause regression of a …

Contact-dependent cell interactions determine hormone responsiveness and desensitization in rat granulosa cells

F Harandian, R Farookhi - Endocrinology, 1998 - academic.oup.com
The maintenance of associations between granulosa cells (GCs) is necessary for FSH-
stimulated induction of LH receptors. In cultures in which these associations have been …

Formulations comprising antisense nucleotides to connexins

RC Green, DL Becker - US Patent 7,902,164, 2011 - Google Patents
A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide
to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful …

EGF 对人视网膜色素上皮细胞胞间通讯功能和Cx43 表达的影响

王凤翔, 何守志, 顾峥, 陈兵 - 眼科新进展, 2005 - cqvip.com
目的探讨培养的人视网膜色素上皮(retinal pigment epithelium, RPE) 细胞中连接蛋白Cx43
的表达, 以及表皮生长因子(epidermal growth factor, EGF) 对人视网膜色素上皮细胞间缝隙连接 …

Quiescent mammary epithelial cells have reduced connexin43 but maintain a high level of gap junction intercellular communication

MA Sia, TL Woodward, JD Turner… - Developmental …, 1999 - Wiley Online Library
Gap junctions have been implicated in growth control, but it remains unclear whether cells
that enter a quiescent state continue to express connexins and maintain a high level of gap …

Potent inhibition of gap junctional intercellular communication by 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX) in BALB/c 3T3 cells

P Hakulinen, J Mäki-Paakkanen, J Naarala, L Kronberg… - Toxicology letters, 2004 - Elsevier
The chlorohydroxyfuranones (CHFs) MX [3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-
furanone], MCA [3, 4-dichloro-5-hydroxy-2 (5H)-furanone], CMCF [3-chloro-4-(chloromethyl) …

表皮生长因子对人视网膜色素上皮细胞Cx43mRNA 表达的影响

王凤翔, 何守志, 顾峥, 梁秋丽, 陈兵 - 国际眼科杂志, 2006 - cqvip.com
目的: 观察表皮生长因子(epidermal growth factor, EGF) 对培养的人视网膜色素上皮(retina
pigment epithelium cell, RPE) 细胞中缝隙连接蛋白Cx43 蛋白及mRNA 的表达影响. 方法 …

Blockade of connexin 43 expression by stable transfection of antisense cDNA in cultured vascular smooth muscle cells

Y Liao, BR Duling - Antisense and Nucleic Acid Drug Development, 2000 - liebertpub.com
Gap junctional communication is involved in embryogenesis, cell growth control, and
coordinated contraction of cardiac myocytes. It has been hypothesized that gap junctions …

[PDF][PDF] Mechanism of Ca2+-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels. Biology 2021, 10, 743

EA Turovsky, EG Varlamova - 2021 - researchgate.net
To date, there are practically no data on the mechanisms of the selenium nanoparticles
action on calcium homeostasis, intracellular signaling in cancer cells, and on the …

Methods of treatment by administering anti-connexin proteins and mimetics

CR Green, DL Becker - US Patent 9,248,141, 2016 - Google Patents
Methods and compositions for modulating the activities of connexins are provided, including,
for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and …