Endogenously produced pro-oxidant reactive species are essential to life, being involved in
several biological functions. However, when overproduced (eg due to exogenous …

Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix
(ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of …

Tumor cell metastasis is facilitated by" premetastatic niches" formed in destination organs by
invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for …

Lung cancer is the leading cause of cancer-related deaths, primarily due to distant
metastatic disease. Metastatic lung cancer cells can undergo an epithelial-to-mesenchymal …

Abstract VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in
angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its …

More than 90% of cancer patient mortality is attributed to metastasis. In this study, we
investigated a role for the lysyl oxidase-related enzyme lysyl oxidase-like 2 (LOXL2) in …

Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in
collagens and elastin, resulting in the covalent crosslinking and stabilization of these …

Thoracic aortic aneurysms and dissections (TAAD) represent a substantial cause of
morbidity and mortality worldwide. Many individuals presenting with an inherited form of …

Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when
surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta …

Lysyl oxidase (LOX) is an enzyme responsible for the cross-linking of collagen and elastin
both in vitro andin vivo. The unique functions of the individual members of this multigene …