Vascular inflammation and oxidative stress: major triggers for cardiovascular disease

S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

[HTML][HTML] Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes

JS Yun, SH Ko - Metabolism, 2021 - Elsevier
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in
patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades …

Pancreatic regulation of glucose homeostasis

PV Röder, B Wu, Y Liu, W Han - Experimental & molecular medicine, 2016 - nature.com
In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Insulin resistance and hyperglycaemia in cardiovascular disease development

M Laakso, J Kuusisto - Nature reviews endocrinology, 2014 - nature.com
The prevalence of diabetes mellitus will likely increase globally from 371 million individuals
in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 …

SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

DM Lee, ML Battson, DK Jarrell, S Hou… - Cardiovascular …, 2018 - Springer
Abstract Background Type 2 diabetes (T2D) is associated with generalized vascular
dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and …

[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Hypomagnesemia and cardiovascular risk in type 2 diabetes

LJ Oost, CJ Tack, JHF de Baaij - Endocrine Reviews, 2023 - academic.oup.com
Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in
the healthy population. Factors that are involved in this high prevalence are low Mg2+ …

Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications

RB Goldberg - The Journal of Clinical Endocrinology & …, 2009 - academic.oup.com
Context: Recent developments indicate that pathophysiological mechanisms leading to β-
cell damage, insulin resistance, and the vascular complications of diabetes include an …

Mechanisms involved in the development and healing of diabetic foot ulceration

T Dinh, F Tecilazich, A Kafanas, J Doupis… - Diabetes, 2012 - Am Diabetes Assoc
We examined the role of vascular function and inflammation in the development and failure
to heal diabetic foot ulcers (DFUs). We followed 104 diabetic patients for a period of …

Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

CDA Stehouwer, RMA Henry, I Ferreira - Diabetologia, 2008 - Springer
Increased arterial stiffness associated with diabetes and the metabolic syndrome may in part
explain the increased cardiovascular disease risk observed in these conditions. Arterial …