BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins
which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the …

Richter transformation (RT), defined as the development of an aggressive lymphoma on a
background of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) …

Richter transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) that
has dismal outcomes. Upregulation of PD-1/PD-L1 drives immunological evasion in patients …

In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the
development of an aggressive lymphoma that is associated with poor response to …

Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Richter's syndrome (RS) is an aggressive histologic transformation of chronic lymphocytic
leukemia (CLL), most commonly to diffuse large B-cell lymphoma (DLBCL). Outcomes are …

Richter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the
most prevalent leukemia among adults, into a highly aggressive lymphoproliferative …

Simple Summary Chronic lymphocytic leukemia represents the most frequent leukemia in
adults and evolves from an indolent phase to an aggressive lymphoma in 5–10% of the …

Simple Summary Though rare, Richter Transformation (RT) is a serious complication of
chronic lymphocytic leukemia. RT carries a high mortality rate and represents an unmet …

Introduction Tumor lysis syndrome (TLS), which occurs spontaneously or in response to
anticancer treatment, results in the release of intracellular potassium, phosphorus, and …