Congenital muscular dystrophy, caused by mutations in LAMA2 (the gene encoding laminin
α2 chain), is a severe and incapacitating disease for which no therapy is yet available. We …

Muscular dystrophies, including laminin α2 chain-deficient muscular dystrophy (LAMA2-
CMD), are associated with immense personal, social and economic burdens. Thus, effective …

Key points Many studies have previously suggested the existence of stress hormone
receptors on the cell membrane of many cell types, including skeletal muscle fibres; …

Extracellular matrix surrounding Schwann cells and neurons provides critical determinants
of cellular phenotype during development as well as essential cues in stimulating and …

Among diseases affecting skeletal muscle, muscular dystrophy is one of the most
devastating and complex disorders. The term 'muscular dystrophy'refers to a heterogeneous …

Congenital muscular dystrophy with laminin α2 chain-deficiency (LAMA2-CMD) is a severe
neuromuscular disorder without a cure. Using transcriptome and proteome profiling as well …

As the complexities of dystrophic pathology have been elucidated over the last few years, it
has become increasingly clear that primary monogenetic defects result in multiple …

The extracellular matrix (ECM) comprises of many structural molecules that constitute the
extracellular environment. ECM molecules are characterized by specific features like …

Extracellular matrix (ECM) myopathies and muscular dystrophies are a group of genetic
diseases caused by mutations in genes encoding proteins that provide critical links between …

Multipotent mesenchymal stromal cells (MSCs) are well known for their tri-lineage potential
and ability to differentiate in vitro into osteogenic, chondrogenic or adipogenic lineages. By …