Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers.
However, we lack experimental models for validating their tumorigenic impact. Here, we …

Medulloblastoma (MB) is the most common malignant childhood brain tumour,, yet the origin
of the most aggressive subgroup-3 form remains elusive, impeding development of effective …

Human cerebellar development is orchestrated by molecular regulatory networks to achieve
cytoarchitecture and coordinate motor and cognitive functions. Here, we combined single …

The expansion of the neocortex, a hallmark of mammalian evolution,, was accompanied by
an increase in cerebellar neuron numbers. However, little is known about the evolution of …

Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-
altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs) …