ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis

MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian …

X Li, X Meng, M Timofeeva, I Tzoulaki, KK Tsilidis… - Bmj, 2017 - bmj.com
Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …

[HTML][HTML] Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases

A Taleb, KA Ahmad, AU Ihsan, J Qu, NA Lin… - Biomedicine & …, 2018 - Elsevier
Cardiovascular diseases (CVDs) are considered as the major reason for mortality and
morbidity worldwide. Substantial evidence suggests that increased oxidative stress plays a …

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

K Raedschelders, DM Ansley, DDY Chen - Pharmacology & therapeutics, 2012 - Elsevier
Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Vascular endothelium dysfunction: a conservative target in metabolic disorders

S Jamwal, S Sharma - Inflammation Research, 2018 - Springer
Aim Vascular endothelium plays a role in capillary transport of nutrients and drugs and
regulates angiogenesis, homeostasis, as well as vascular tone and permeability as a major …

[HTML][HTML] Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults

M Chen, Y Li, Q Sun, A Pan, JAE Manson… - The American journal of …, 2016 - Elsevier
Background: Few prospective studies have examined dairy fat in relation to cardiovascular
disease (CVD) Objective: We aimed to evaluate the association between dairy fat and …

[HTML][HTML] The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: molecular mechanisms and clinical implications

P Puddu, GM Puddu, E Cravero, L Vizioli, A Muscari - Journal of cardiology, 2012 - Elsevier
Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is
converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid …

[HTML][HTML] Reactive oxygen species and antioxidant defense in human gastrointestinal diseases

P Patlevič, J Vašková, P Švorc Jr, L Vaško… - Integrative medicine …, 2016 - Elsevier
Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases
(IBDs), and celiac disease are the most common disorders affecting not only adults but also …

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

A Ives, J Nomura, F Martinon, T Roger, D LeRoy… - Nature …, 2015 - nature.com
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires
intracellular generation of reactive oxygen species (ROS). We present evidence that …